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Mirth® Connect supports both session-based cookie authentication and basic authentication.
Basic Authentication:
Authorization: Basic YWRtaW46YWRtaW4=
Session-Based Authentication:
Set-Cookie: JSESSIONID=uysqrtx9lle36ernybizstps;Path=/api;Secure
Cookie: JSESSIONID=uysqrtx9lle36ernybizstps;Path=/api;Secure
Session-based Authentication is preferred since you only need to transmit your login credentials once.
Note that the API documentation page invokes the same endpoint automatically when you login at the top: